Customization: | Available |
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CAS No.: | 320-67-2 |
Shelf Life: | 3 Years |
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Quick Details
Product Name:5-Azacytidine
Synonyms:Antibiotic U 18496-15N4;Azacitidine-15N4
CAS:320-67-2
MF:C8H12N4O5
MW:244.2
EINECS:206-280-2
Melting point:226-232 °C (dec.)(lit.)
Alpha:40 º (C=1, H2O 22 ºC)
Storage temp.: 2-8°C
Form:lyophilized powder
Color:White to Off-white
Water Solubility: 0.5-1.0 g/100 mL at 21 ºC
Purity:99%
Appearance: White powders
Package:1kg/25kg/package
Introduction
Azacitidine (INN; trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative, decitabine (also known as 5-aza-2′deoxycytidine), are used in the treatment of myelodysplastic syndrome. Both drugs were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.
Specifications
Product name |
5-Azacytidine |
Other name | 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one |
Specification |
EP/USP |
CAS |
320-67-2 |
Package | 25kg net per drum. |
Stock | Fresh stock; good price; samples available |
Molecular Structure | |
Molecular Formula |
C8H12N4O5 |
Molecular Weight | 244.21 |
Uses
Usage: It is a kind of antimetabolite. The main indications are acute myeloid leukemia which cannot be cured with routine therapy, breast cancer, melanoma, colorectal cancer, etc. The main toxicity includes leukopenia, thrombocytopenia and anemia. Nausea and vomiting are common adverse reactions, which can be improved by through long time continuous infusion and using antiemetic 12h or 24 h before treatment.It is a powerful growth inhibitor and cytotoxic agents which inhibits the DNA methyltransferase, an important mechanism for gene expression, Gene activation and silence and a kind of cancer treatment additives with weak antibody activity (gram-positive) used to study the Effect of Combining DNA Molecular in the process of DNA methylation .
Packing:
Shipping Terms | ||
By Express | By Air | By Sea |
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods |
Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed |
Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed |