| Customization: | Available |
|---|---|
| CAS No.: | 144701-48-4 |
| Shelf Life: | 3 Years |
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Product Name: Telmisartan
CAS: 144701-48-4
MF: C33H30N4O2
MW: 514.62
EINECS: 620-494-7
Melting point: 261-263°C
Boiling point: 771.9±70.0 °C
Storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Description:
Telmisartan, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid (Micardis), does not appear to bear any structuralrelationship to this class, but there is actually a great dealof overlap in the chemical architecture with other agents.
The first, and most significant, difference is the replacement of the acidic tetrazole system with a simple carboxylic acid. This acid, like the tetrazole, plays a role in receptor binding.
The second difference is the lack of a carboxylic acid near the imidazolenitrogen that also contributes to receptor binding.As with irbesartan, however, there is not a need for this groupto be acidic but, rather, to be one that participates in receptorbinding. The second ring, much like a purine basein deoxyribonucleic acid (DNA), can hydrogen bond with theangiotensin II receptor.
Usage:
Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus.
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