High Quality Carfilzomib CAS 868540-17-4 Treatment of Bone Marrow Tumour

• Customization: Available
• CAS No.: 204656-20-2
• Shelf Life: 3 Years
• Grade: Pharmaceutical Grade
• Product Name: Carfilzomib
• Transport Package: Vials
• Specification: cusmoerised
• Trademark: OEM/ODM
• Origin: Fujian China
• Production Capacity: 100kg Per Month

Product Description

 

Products Description

High Quality Carfilzomib CAS 868540-17-4 Treatment Of Bone Marrow Tumour
Product Name:    Carfilzomib
Synonyms:    N-{(2S)-2-[(Morpholin-4-ylacetyl)aMino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-Methyl-1-[(2R)-2-Methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninaMide;CarfilzoMib salt;CarfilzoMib/PR 171;PR 171;PR-171 (CarfilzoMib);(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamide;Carfilzomib;Carfilzomib API and intermediates
CAS:    868540-17-4
MF:    C40H57N5O7
MW:    719.92
EINECS:    692-054-2
Product Categories:    Inhibitors;peptides;Inhibitor;API;Pharmaceutical
Mol File:    868540-17-4.mol


Carfilzomib is an irreversible proteasome inhibitor and antineoplastic agent.The mechanism of action of carfilzomib is as a Proteasome Inhibitor, Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
Carfilzomib is used in treatment of refractory multiple myeloma. Carfilzomib is associated with a low rate of serum enzyme elevations during treatment and has been implicated to rare instances of clinically apparent, acute liver injury some of which have been fatal.

Carfilzomib CAS 868540-17-4 of Chemical Properties
Melting point     204 - 208°C
Boiling point     975.6±65.0 °C(Predicted)
density     1.161
Fp     543.8ºC
storage temp.     -20°
solubility     Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 25 mg/ml).
form     solid
pka    13.17±0.46(Predicted)
color     White
Stability:    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
CAS DataBase Reference    868540-17-4

Function and Application of Carfilzomib CAS 868540-17-4
Carfilzomib (CAS 868540-17-4) is a medication used in the treatment of multiple myeloma, a type of blood cancer that affects the plasma cells in the bone marrow. Carfilzomib belongs to a class of drugs called proteasome inhibitors, which work by blocking the activity of proteasomes, structures within cells that break down proteins. This leads to the accumulation of abnormal proteins within the cancer cells, which can ultimately lead to their death.

Function:
The primary function of carfilzomib is to inhibit the activity of proteasomes, which are responsible for breaking down proteins within cells. By blocking the proteasomes, carfilzomib prevents the degradation of certain proteins that are essential for the survival and growth of cancer cells. This ultimately leads to the death of the cancer cells.

Application:
Carfilzomib is mainly used in the treatment of multiple myeloma, which is a type of blood cancer that affects the plasma cells in the bone marrow. It is often used in combination with other medications, such as dexamethaso ne, to help improve the overall effectiveness of the treatment. Carfilzomib may also be used in the treatment of other types of cancer, such as lymphoma and solid tumors, although this is less common.



Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Tirzepatide, is a medication used for the treatment of type 2 diabetes.  Tirzepatide is given by weekly subcutaneous injection (under the skin).

Glucagon-like peptide-1 and glucose-dependent insuli otropic polypeptide are hormones involved in blood sugar control.  After a person has eaten, these hormones are secreted by cells of the intestines and in turn cause the secretion of insuli.  Tirzepatide is a first-in-class medication.  It is a GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood sugar control.

Function

• Helps slow food leaving your stomach
• Helps prevent your liver from making too much sugar
• Helps the pancreas produce more insul when your blood sugar levels are high
• Can help control blood glucose
• Can reduce hyperglycemia, especially after meals
• Can reduce fasting insul and fasting glucose
• Can reduce hemoglobin A1c
• Can decrease appetite and caloric intake, while inhibiting weight gain
• Has been shown to lower triglyceride levels and oxidative stress from high LDL
• Has been shown to help induce weight loss in obese patients with higher dosing
• Helps decrease leptin and increase leptin sensitivity
• Can increase the conversion of white fat to brown fat
• 

 

 

 

our company 


 Hebei xianri biotechnology co.,ltd mainly focusing on dietary supplements processing in China, providing wide range of natural products with different forms including softgel, tablet, Capsules, vegetables hard capsules, powder and gummy. our R&D department providing value-added OEM and private label services for you.

Our company covers an area of 8 hectares and we have over 600 workers and staff members ,we owns five dietary supplement processing factories and two marine raw material extracting factories , which have passed the quality management certifications of GMP cGMP,HACCP,U.S.FDA,ISO9001,ISO14001,OHASAS18001 and BRC for global retails. We have imported 18 large soft gel production lines and more than 20 pieces of production equipment, such as fully automatic tablet compressing machines, hard capsule filling machines,3D mixers and coating machines, our daily production capacity of 20 million pieces of nutritional supplements and more than 1200 health products , bottling capability of 150 thousand bottles. We are largest production base of dietary supplements in Asia.

FAQ
How to contact us:
 
 
 
Address: No.392 Huaibei Road,Yuhua Districe, Shijiazhuang,China.
Our Payment Terms: 
Payment terms: 30% TT in advance as deposit for us to start the production, and the balance should be
TT after the shipment and before the seller release the Original B/L to buyer. 

Q: When can I get the price?
A: We usually quote within 24 hours after we get your inquiry.
If you are very urgent to get the price, please tell us so that we will regard your inquiry priority.
Q: How can I get a sample to check your quality?
A: After price confirmation, we are happy for sending samples in 2 days to you once you need.
Q: What about the lead time for mass production?
A: Honestly, it depends on the order quantity and the season you place the order. Always 1 month.
Q: What is your terms?
A: W accept EXW, FOB, CFR, CIF, DDU, DDP, etc. You can choose the one which is the most
convenient or cost effective for you.


To get more information, just feel free to contact with us. 
Sincerely looking forward to your cooperation.